Physicians' Academy for Cardiovascular Education

Beneficial effects of antihypertensive therapy on central hemodynamics

Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension. The PARAMETER Study

Literature - Williams B, Cockcroft JR, Kario K, et al. - Hypertension. 2017;69: published online ahead of print

Main results


In elderly patients with elevated SBP and PP, sacubitril/valsartan was superior compared with olmesartan in reducing sitting and ambulatory central aortic and brachial pressures. The greater reduction in NT-proBNP and PP observed with sacubitril/valsartan indicates a de-stiffening effect of sacubitril/valsartan and a reduction in cardiac wall stress. These findings suggest that sacubitril/valsartan provides beneficial effects on central aortic hemodynamics.


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