Physicians' Academy for Cardiovascular Education

Red yeast rice component resembles lovastatin and may yield similar adverse events

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Literature - Mazzanti G, Moro PA, Raschi E et al., - British Journal of Clinical Pharmacology. First published: 19 January 2017. DOI: 10.1111/bcp.13171

Main results

Reported cases are described in detail in the article


These observations raise the hypothesis that the safety profile of RYR is similar to synthetic statins, as myopathies, cutaneous reactions, gastrointestinal and liver reactions emerged as potential safety signals. Clinicians should be aware of the fact that monacolin K contained in RYR is identical to lovastatin. Therefore, early monitoring of liver function and signs of muscle injury should be considered, and self-medication with RYR should be discouraged, especially in those who previously experienced adverse reactions to statins.


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