Physicians' Academy for Cardiovascular Education

Interrupting sitting time as a means to improve glucose metabolism in T2DM

Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes.

Literature - Duvivier BM, Schaper NC, Hesselink MK et al., - Diabetologia. 2016. doi:10.1007/s00125-016-4161-7

Main results


These data show that the Sit Less regimen improved insulin sensitivity, mean 24 h glucose levels, 24h glucose excursions, duration of hyperglycaemia and fasting triacylglycerol levels. In this study, the general effect of the Sit Less regimen on glucose homeostasis tended to be a little more potent than the effect of structured exercise. Insulin sensitivity was more improved after the Sit Less regimen than after the Exercise regimen. In this respect is it interesting to note that during the Exercise regimen participants spent most of the day sitting. It is thus proposed that the duration of non-sitting activities may be more important than the intensity of these activities.

The volume of light-intensity activities in this study was relatively high as compared with what is generally observed in T2DM patients, thus future studies may establish what activity regimen might be more feasible.


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