Physicians' Academy for Cardiovascular Education

No association non-fasting triglycerides with subclinical atherosclerosis

Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima media thickness in the middle aged: the NEO study

Literature - Christen T, de Mutsert R, Gast KB, et al. - J Clin Lipidol, 2017, In press

Main results

Conclusion

There was a clear association between fasting TGc and IMT, which persisted after adjustment for postprandial TG response over 150 minutes. However, the association observed between crude TG response after a meal and IMT disappeared after adjusting for fasting TGc. These results imply that non-fasting and fasting TGc may not be exchangeable and that it may not be useful to perform a meal challenge in order to estimate a person’s risk of atherosclerosis. The association between TG response and IMT remained in smokers and pre-diabetics/diabetics after adjustment for fasting TGc, which may indicate that these conditions increase the susceptibility of the endothelial wall to either postprandial TG response or higher concentrations of remnant particles.

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