Physicians' Academy for Cardiovascular Education

Non-HDL-C a better predictor of mortality than LDL-C

Usefulness of Non-High Density Lipoprotein Cholesterol as a Predictor of Cardiovascular Disease Mortality in Men in 22 Year Follow Up

Literature - Harari G, Green MS, Magid A, et al. - Am J Cardiol 2017; published online ahead of print

Main results

Conclusion

In a large population of young males who were followed-up for 22 years, non-HDL-C was a more potent predictor of CVD mortality compared with LDL-C levels, after adjustment for many relevant confounding factors. These findings support existing data, according to which, non-HDL-C should be preferred over LDL-C for CV risk stratification. Interestingly, higher levels of non-HDL-C seemed to attenuate the “protective” effect of lower levels of LDL-C, although these results need to be confirmed in larger studies.

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