No gain or loss of gait speed with strict BP control in elderly SPRINT participants
Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trialNews - Feb. 16, 2017
- Overall mean gait speed at baseline was 0.91 m/s, with a mean annual change of -0.026 (95%CI: -0.028 to -0.023) m/s.
- Both treatment groups showed a similar trajectory of gait speed; the decline in mean gait speed was the same for those randomised to intensive or standard treatment (mean difference: 0.004 m/s per year, 95%CI: -0.005 to 0.005 m/s per year, P=0.88).
- Change in gait speed were not significantly different between subgroups defined by age, sex, race or ethnicity, baseline SBP, chronic kidney disease, or history of CVD.
- Assessment of mobility status was based on self-report. Overall, the mean transition rate from no mobility limitation to mobility limitation was 12.5 per 100 person-years.
- No significant effect of intensive treatment on transitioning to mobility limitation (HR: 0.92, 95%CI: 0.91-1.22) or transitioning into a limitation-free state (HR: 0.92, 95%CI: 0.77-1.10).
These data of individuals aged 75 years and older, enrolled in the SPRINT trial, show no differences in gait speed decline between those receiving intensive BP-lowering therapy vs. standard therapy. Nor were differences seen between the groups in mobility limitations, based on self-reports.