Physicians' Academy for Cardiovascular Education

Inhibition of hepatic apoC-III synthesis lowers atherogenic VLDL-associated lipoproteins

Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

Literature - Pechlaner R, Tsimikas S, Yin X, et al. - J Am Coll Cardiol 2017;69:789-800

Main results


The apolipoproteins apoC-III, apoC-II, and apoE that are found on triglyceride-rich lipoproteins regulate their metabolism. They were found to be stronger predictors of CV events compared with other apolipoproteins, including apoB-100. The inhibition of hepatic apoC-III synthesis with volanesorsen has favourable effects on apolipoprotein and lipid profiles, and might represent a new approach to further reduce of CVD risk.


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