Physicians' Academy for Cardiovascular Education

Individuals at high genetic risk have greater benefit from statins

Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting

Literature - Natarajan P, Young R, Stitziel NO, et al. - Circulation. 2017; CIRCULATIONAHA.116.024436

Main results

Conclusion

Although levels of LDL-c reduction were comparable, men with a high genetic risk derived a greater relative benefit from statin therapy. Furthermore, an expanded 57-SNP score was associated with subclinical atherosclerosis in two vascular beds. High genetic risk may identify individuals eligible to statins to prevent a first myocardial infarction event who otherwise would not be considered for treatment based on clinical criteria. This hypothesis can be tested in more contemporary cohorts with sizable proportions of statin-ineligible patients.

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