Physicians' Academy for Cardiovascular Education

Quadpill lowers blood pressure

Small randomized, placebo-controlled crossover trial shows that pill containing four drugs at quarter-dose achieved blood pressure-lowering without additional side effects.

Literature - Chow CK, Thakkar J, Bennett A, et al. - Lancet. 2017 Feb 9, Epub ahead of print

Main results


This small, randomized, placebo-controlled crossover trial showed blood pressure-lowering when using a capsule containing four blood pressure-lowering drugs each at quarter-dose. Systematic reviewing of trials that used one or two drugs at quarter-dose, revealed similar findings of a large benefit without additional side effects. This novel approach need further study to assess the contributions of different components and the long-term efficacy and safety in a broader population.


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Find this article online at The Lancet

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