Physicians' Academy for Cardiovascular Education

Factor Xa inhibitor more effective than aspirin for long-term prevention of recurrent VTE

Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism

Presented at ACC.17 by Philip S. Wells

News - Mar. 18, 2017

Main results


Rivaroxaban, at both a treatment dose (20 mg) and a thrombo-prophylactic dose (10 mg), was more effective than aspirin for the prevention of recurrent VTE in patients for whom there was uncertainty about the benefit of continued anticoagulation. Rates of bleeding were similar between all treatment groups.

During the press conference, dr. Wells concluded that these data show that there is no role for aspirin in the extended phase of prevention of recurrent VTE.

Editorial comment

In their editorial article, Crowther and Cuker provide an interpretation of the findings of the Weitz et al study, by considering them as qualitative evidence supporting the long-term use of low dose rivaroxaban, in particular for patients with provoked venous thromboembolism at median risk for bleeding and high risk for a recurrent thromboembolic event.

The authors conclude: ‘The emergence of rivaroxaban and other direct oral anticoagulant agents has altered the standard of care among patients with venous thromboembolism. For patients without cancer, the use of direct oral anticoagulant agents might be considered as first-line treatment for those with acute venous thromboembolism. Full-dose treatment could be continued for a minimum of 3 to 6 months. In patients in whom there is equipoise with respect to continuing anticoagulant therapy beyond this period, the use of a reduced-intensity direct oral anticoagulant agent might be considered. Clinicians who choose this strategy can be confident of excellent efficacy and low bleeding risk similar to that observed with aspirin or placebo.’

This article was published today in NEJM

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