Physicians' Academy for Cardiovascular Education

No effect of PCSK9 inhibitor on cognitive functioning in CVD patients, even at LDL-c <25 mg/dL

Primary Results of EBBINGHAUS, a Cognitive Study of Patients Enrolled in the FOURIER Trial

Presented at ACC.17 by Robert P. Giugliano

News - Mar. 18, 2017

Main results


These data show that in patients with known CVD on background statin followed for 20 months, no differences were seen between patients receiving evolocumab and placebo in a battery of cognitive tests, in patient-reported everyday cognition, nor in adverse cognitive events reported by a physician. There was no evidence of a difference in cognitive tests by achieved nadir LDL-c, even below 25 mg/dL. No decline in cognitive function was seen between beginning and end of study, in either treatment group.

During the press conference, the experts on the panel referred to dr. Google, who often misinforms patients and keeps myths about possible risks alive. The commenter noted that these data are very reassuring that PCSK9 inhibition with evolocumab is not associated with cognitive decline in those with low LDL-c, nor in the population as a whole.

While the study did not specifically address the question whether statins are associated with cognitive decline, no change in cognitive function was observed over time in the placebo group, meaning patients on statin therapy.

A question was asked about the diverging CV event curves seen in the FOURIER trial over time, and whether a similar effect might be anticipated for the cognitive effects. Longer term cognitive effects will also be assessed in the open label extension study, in which EBBINGHAUS patients can enrol. Obviously, long term information will be informative, but dr. Giugliano shared that for this type of cognitive studies, the set up of EBBINGHAUS was already relatively long and large. He does not expect big surprises, considering that reaction time only decreased by 2-5 ms over the course of months, which is much smaller than the effect of having an alcohol permillage just over the limit allowed for driving (175 ms) or taking a benzodiazepine (30-40ms).


Our coverage of ACC.17 is based on the information provided during the congress.

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