Physicians' Academy for Cardiovascular Education

Revascularisation on non-infarct-related lesions during primary PCI in STEMI patients

Fractional Flow Reserve–Guided Multivessel Angioplasty in Myocardial Infarction

Presented at ACC.17 by Pieter C Smits

News - Mar. 18, 2017

Main results


In STEMI patients with multi-vessel disease, FFR-guided complete revascularisation of non–infarct-related lesions in the acute phase of primary PCI, reduced the risk of a composite CV outcome compared with the treatment of the infarct-related artery only. These findings suggest that FFR might be useful for deciding whether non-infarct-related arteries should be re-opened in the acute STEMI setting, or not.

Editorial comment

In his editorial article, Køber doubts that the results of the Smits et al study can be extrapolated to every day clinical practice, since the patients included in the study had a lower risk than average, and were not negatively influenced by the prolongation of the index procedure. Moreover, information about eligible patients who were not randomised is missing, and the treatment allocation was not blinded. The author concludes:

‘When considered together with previously published data, the report by Smits and colleagues indicates that a strategy of FFR-guided complete revascularization results in lower rates of major adverse cardiovascular events and of revascularization procedures performed than a strategy based only on angiography. However, the cardiovascular benefit was driven largely by revascularization. Larger trials powered for hard end points (recurrent myocardial infarction or cardiovascular mortality) are needed to determine the effects of an FFR-guided complete-revascularization strategy on these outcomes and to identify the subgroups of patients most likely to benefit (recruitment is ongoing in one trial of 3900 patients [ number, NCT01740479]).’

This study was published today in NEJM

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