Physicians' Academy for Cardiovascular Education

DPP4 inhibitor is safe in older diabetic participants

Assessing the Safety of Sitagliptin in Older Participants in the Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS)

Literature - Bethel AM, Engel SS, Green JB, et al. - Diabetes Care 2017; published online ahead of print

Main results


In a large group of participants ≥75 years with well-controlled diabetes, sitagliptin did not increase the risk of serious hypoglycaemia and was neutral with respect to CV outcomes during 3 years of follow-up. These results contribute to better decision making, when it comes to the treatment of older diabetic patients in clinical practice.


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