Physicians' Academy for Cardiovascular Education

No convincing evidence of measurable verbal or nonverbal memory dysfunction due to statin

The Effect of High-Dose Atorvastatin on Neural Activity and Cognitive Function

Gepresenteerd tijdens ACC.17 door Beth Taylor

News - Mar. 23, 2017

Main results

Conclusion

This study showed few changes between treatment groups in standardised neuropsychological tests, which is congruent with large clinical trials.

Case reports of memory decrements with statin therapy continue to be published, and patients report cognitive side effects as a leading cause of statin intolerance. It is unclear to date whether this is due to a nocebo effect. Methodological issues (small effect sizes, learning/practice effects) may also play a role.

This study was the first to investigate the effects of statins on the CNS using fMRI. No convincing evidence of measurable verbal or nonverbal memory dysfunction due to statin medications was found. Most regional networks activated similarly by both groups. Patients on atorvastatin demonstrated small but significantly altered patterns of regional neural activation on vs. off statin, as compared to participants on placebo. The clinical implications of these findings are unclear and warrant additional clinical trials.

Disclosures

Our coverage of ACC.17 is based on the information provided during the congress.

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