Physicians' Academy for Cardiovascular Education

Triglyceride plus HDL-C level identifies subpopulations at increased risk of CHD or stroke

Triglyceride and HDL-C Dyslipidemia and Risks of Coronary Heart Disease and Ischemic Stroke by Glycemic Dysregulation Status: The Strong Heart Study

Literature - Lee JS, Chang P-Y, Zhang Y, et al. - Diabetes Care 2017; published online ahead of print


High triglyceride (TG) levels and low HDL-C levels, which are risk factors for coronary heart disease (CHD) and ischaemic stroke, remain prevalent in statin-treated patients [1-3]. It is important to elucidate whether the risk of incident CHD or ischaemic stroke is different for distinct populations [4,5].

In this study, it was evaluated whether the association of high TG and low HDL-C levels with increased risk of CHD and ischaemic stroke, depends on diabetes mellitus (DM) status, gender and LDL-C levels, in a population of American Indians who have a high prevalence of obesity and diabetes (Strong Heart Study [SHS]).

Main results


In a prospective cohort study, high fasting TG levels in combination with low HDL-C levels were associated with increased risks of incident CHD and ischaemic stroke, particularly in patients with diabetes or with an LDL-C level of ≥130 mg/dL, independently of other CVD risk factors. These results may contribute to the optimisation of lipid-lowering therapies.


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