Physicians' Academy for Cardiovascular Education

Very low LDL-C levels are safe and effective in high-risk post-ACS patients

Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol: A Prespecified Analysis of the IMPROVE-IT Trial

Literature - Giugliano RP, Wiviott SD, Blazing MA, et al. - JAMA Cardiol. 2017; published online ahead of print

Main results


Very low LDL-C levels at 1 month were associated with a similar safety profile compared with higher LDL-C levels. Moreover, LDL-C levels below currently recommended targets were associated with even further numerical reductions in CV events. These results support the use of intensive lipid-lowering therapy in very high-risk post-ACS patients.


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