Physicians' Academy for Cardiovascular Education

Increased inflammatory activation in patients with familial dysbetalipoproteinaemia

Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans

Literature - Bernelot Moens SJ, Verweij SL, Schnitzler JG, et al. - Arterioscler Thromb Vasc Biol. 2017;37: published online ahead of print

Main results

Conclusion

Patients with FD have increased arterial wall and cellular inflammation, as well as increased bone marrow activation. These findings suggest that additional pathophysiological processes lead to the atherogenicity of remnant cholesterol that contributes to the increased cardiovascular disease risk in these patients.

References

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