Physicians' Academy for Cardiovascular Education

Large majority of AF patients who suffered from stroke were not adequately anticoagulated

Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation

Literature - Xian Y, O’Brien EC, Liang L et al., - JAMA. 2017;317(10):1057-1067. doi:10.1001/jama.2017.1371

Main results


In this nationwide, contemporary registry of patients with a known history of AF who had experienced an acute ischemic stroke, 84% did not receive guideline-recommended anticoagulation or had subtherapeutic anticoagulation levels. This affects clinical outcomes, as preceding coagulation with NOACs or therapeutic warfarin was associated with less severe stroke and fewer deaths during the hospital stay.


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