Levels of physical activity may outweigh CVD risk due to overweight and obesity
Impact of physical activity on the association of overweight and obesity with cardiovascular disease: The Rotterdam StudyLiterature - Koolhaas CM, Dhana K, Schoufour JD, et al. - Eur J Prev Cardiol 2017; published online ahead of print
- Based on the quantity of PA, 2 groups were created: the high PA group exercised 111.3 MET∙hours∙week-1 (IQR 93.7–139.6) and the low PA group exercised 54.6 MET∙hours∙week-1 (IQR 39.0–67.5).
- The participants with low PA levels were more often male, older and current smokers compared with those with a high PA level.
- Compared with normal weight participants, overweight (HR 1.13, 95% CI 0.97–1.57) or obese (HR 1.20, 95% CI 0.99–1.46) participants were not at significantly increased CVD risk. P for trend across BMI categories was 0.05.
- Compared with the higher PA level (irrespective of obesity), participants with a low PA level were at higher CVD risk (HR 1.22, 95% CI 1.06–1.41).
- Compared with normal weight participants with high PA levels, CVD risk was not significantly different in overweight (HR 1.03, 95% CI 0.82–1.29) or obese (HR 1.12, 95% CI 0.83–1.52) participants with a high PA level.
- Compared with normal weight participants with low PA levels, CVD risk was increased in overweight (HR 1.33, 95% CI 1.07-1.66) or obese (HR 1.35, 95% CI 1.04-1.75) participants with high PA levels.
In this long-term follow-up study, only overweight and obese participants with low PA, and not those with high PA, were at increased risk for CVD, when compared to participants with normal weight. These findings suggests that regular PA reduces CVD risk in these individuals and that further benefits can be gained from maintaining a healthy weight.