Physicians' Academy for Cardiovascular Education

Biomarker levels differ between HFpEF and HFrEF patients

Biomarker Profiles in Heart Failure Patients With Preserved and Reduced Ejection Fraction

Literature - Tromp J, Khan MAF, Klip IT, et al. - J Am Heart Assoc. 2017;6:e003989.

Main results


Biomarker levels differ in HFpEF and HFrEF patients, mainly in the domains of cardiac stretch and inflammation. The angiogenesis marker neuropilin and remodeling marker osteopontin were found to only hold predictive value in HFpEF. The difference in biomarker levels may reflect the different pathophysiology of HFpEF and HFrEF.


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