Physicians' Academy for Cardiovascular Education

Increased risk of acute MI on DOAC vs. VKA in real world AF patients

Risk of myocardial infarction in patients with atrial fibrillation using vitamin K ant agonists, aspirin or direct acting oral anticoagulants

Literature - Stolk LM, De Vries F, Ebbelaar C et al., - Br J Clin P harmacol 2017. DOI: 10.1111/bcp.13264

Main results


This analysis shows that in real-world patients with AF who are currently treated with DOACs or aspirin, the risk of AMI was doubled as compared with current users of VKA. After stratifying for gender, a significantly increased risk was only seen for users of aspirin. When stratifying for stroke risk based on CHA2DS2-VASc score, the risk of AMI remained significantly increased in high and medium risk patients on DOAC and aspirin, as compared with current users of VKAs.


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Find this article online at Br J Clin Pharmacol

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