Physicians' Academy for Cardiovascular Education

Emerging therapeutic areas in lipid management and CV disease

Mar. 16, 2017 - VBWG - ACC 2017 - Sotirios Tsimikas - La Jolla, CA, USA

VBWG ACC 2017 Sotirios Tsimikas summarises the rationale of innovative therapeutic approaches targeting Lp(a), ApoC3 or ATP citric lyase and in what stage of clinical testing they currently are.

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  • Genetically determined Lp(a) levels largely determine CV risk from birth onwards 0:15
  • Therapeutic approaches to lower Lp(a) levels 0:53
  • ApoC3 slows the clearance of triglyceride-rich lipoproteins 3:00
  • ApoC3-antisense therapeutic approaches 3:27
  • Advances of inhibiting ATP citric lyase, an enzyme important for synthesis of both fatty acid and cholesterol 4:23

Educational information

This video was recorded after the Vascular Biology Working Group Meeting at ACC 2017, in Washington, DC, USA.

PACE-cme did not receive financial support for the production of this video.

Disclosures

Sotirios “Sam” Tsimikas - Professor of Medicine, Director of Vascular Medicine, Division of Cardiovascular Diseases, Department of Medicine, UCSD Cardiology La Jolla, Perlman, CA, USA