Physicians' Academy for Cardiovascular Education

Real-world data show clinical benefit of empagliflozin, which is likely a class effect

Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study

Literature - Kosiborod M, Cavender MA, Fu AZ, et al. - Circulation 2017; published online ahead of print

Main results


In a large multinational study, treatment of T2DM patients with SGLT-2 inhibitors versus oGLDs was associated with lower rates of HHF and death in a real-world setting. Since the overwhelming majority of patients did not have established CVD, this suggests that the benefits of SGLT-2 inhibitors on the prevention of heart failure may extend to lower-risk patients than those enrolled in randomized trials so far. Moreover, as there is substantial variation in SGLT2 inhibitor use between geographic regions and no heterogeneity in results was observed across counties, this suggests that there is likely a class effect for SGLT-2 inhibitors.


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Find this article online at Circulation

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