Physicians' Academy for Cardiovascular Education

OxPL on Lp(a) likely a genetic and probably also a causal risk factor for CAVD

Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease - The Copenhagen General Population Study

Literature - Kamstrup PR, Hung M-Y, Witztum JL, et al. - Arterioscler Thromb Vasc Biol. 2017, in press. https://doi.org/10.1161/ATVBAHA.116.308761

Main results

Conclusion

In the CGPS study, both OxPL-apoB and OxPL-apo(a) were genetically and observationally associated with CAVD risk, independent of all other measured risk factors for CAVD (except for Lp(a)). Moreover, OxPL-apoB, OxPL-apo(a) and Lp(a) levels closely correlated. This suggests that OxPL on lp(a) is a genetic and likely causal risk factor for CAVD, which offers opportunities for novel therapeutic approaches for CAVD.

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