Physicians' Academy for Cardiovascular Education

Addition of SBP variability improves risk stratification of diabetic patients

Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes Mellitus: The ADVANCE-ON Study

Literature - Ohkuma T, Woodward M, Jun M, et al. - Hypertension. 2017;70: published online ahead of print

Main results


In diabetic patients, the SBP visit-to-visit variability is an independent predictor of vascular complications and death, which improves the predictive ability of traditional risk factors, including mean SBP. These results support the use of SBP variability for individual risk stratification, and they suggest that the reduction of SBP variability may be an important therapeutic target in these patients.


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