Physicians' Academy for Cardiovascular Education

Metformin may protect against coronary atherosclerosis in men with prediabetes

Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and its Outcome Study on Coronary Artery Calcium

Literature - Goldberg RB, Aroda VR, Bluemke DA, et al, on behalf of the Diabetes Prevention Program Research Group - Circulation 2017; published online ahead of print

Main results

Conclusion

In the Diabetes Prevention Program and its Outcome Study, men, but not women with prediabetes treated with metformin for an average duration of 14 years had lower coronary calcium scores compared with the placebo group. No difference in coronary calcium scores was observed in the group receiving a lifestyle intervention as compared to the placebo group. These findings provide evidence that metformin may protect against coronary atherosclerosis in men with prediabetes.

References

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