Physicians' Academy for Cardiovascular Education

Statin treatment slows progression of carotid atherosclerosis in children with heterozygous FH

Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children with Heterozygous Familial Hypercholesterolemia: The CHARON Study

Literature - Braamskamp MJAM, Langslet G, McCrindle BW, et al. - Circulation 2017; published online ahead of print

Main results


Children with HeFH treated with rosuvastatin had a slower progression of carotid atherosclerosis measured by carotid IMT, diminishing the difference in IMT between them and unaffected siblings.

The rate of progression in carotid IMT was actually less in the HeFH subjects compared with unaffected siblings. This may indicate that more effective therapy also contributes to removal of previously accumulated lipid in the arterial wall; however, further studies are needed to confirm this.

These findings support the value of early initiation of aggressive LDL-C reduction in these patients, for the reduction of their CV risk.


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