Physicians' Academy for Cardiovascular Education

Long-acting statins are also effective when taken in the morning

Effects of Morning Versus Evening Statin Administration on Lipid Profile: A Systematic Review and Meta-Analysis

Awad K, Serban MC, Penson P, et al. - Journal of Clinical Lipidology 2017; published online ahead of print

Background

Statins reduce elevated levels of plasma cholesterol very effectively and are beneficial for the primary and secondary prevention of cardiovascular disease [1-3]. Usually, they are administrated in the evening, since cholesterol biosynthesis peaks during the night and most statins have short half-lives. However, the optimal timing of administration in terms of efficacy and patient compliance is not known [4,5].

In this systematic review and meta-analysis, the different effects of morning and evening statin administration on lipid profiles were evaluated, in order to find the dosing regimen with the highest therapeutic efficacy. For this purpose, studies were included if they 1) were prospective or retrospective clinical controlled studies (randomized or not), 2) compared the effects of morning administration against evening administration of statin therapy on total cholesterol TC, LDL-C, HDL-C or triglycerides (TG) or reported sufficient information on blood lipid levels at baseline and at the end of study in both groups, 3) reporting the net change scores or the mean difference between the change scores of the 2 groups (primary outcome). The secondary outcome was compliance of patients.

Main results

Conclusion

Short-acting statins are significantly more effective in lowering LDL-C and TC when they are administered in the evening, rather than the morning, whereas long-acting statins had a nearly equivalent efficacy irrespective of timing of administration during the day, with the exception of a small but statistically significant effect on LDL-C. These findings confirm that short-acting statins should be taken in the evening and the authors suggest that long-acting statins can also be taken in the morning, if this facilitates patient compliance.

References

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Find this article online at Journal of Clinical Lipidology