Physicians' Academy for Cardiovascular Education

Mutation-carrying relatives of patients with FH are at increased long-term CV risk

Long‐Term Cardiovascular Risk in Heterozygous Familial Hypercholesterolemia Relatives Identified by Cascade Screening

Literature - Kjærgaard KA, Christiansen MK, Schmidt M, et al. - J Am Heart Assoc. 2017;6:e005435

Main results


HeFH relatives with LDLR mutations had an increased long-term risk of adverse CV events compared with non-mutation-carrying relatives and the general population cohort. These results support the importance of cascade screening and aggressive lipid-lowering therapy in families with familial hypercholesterolemia.


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