Physicians' Academy for Cardiovascular Education

Extent of serum cholesterol-lowering associates with survival in homozygous FH

Survival in homozygous familial hypercholesterolemia is determined by the on-treatment level of serum cholesterol

Literature - Thompson GR, Blom DJ, Marais DA, et al. - Eur Heart J 2017; published online ahead of print

Main results

Conclusion

A combined analysis of data from South African and UK homozygotes showed that the extent of reduction of serum cholesterol achieved by a combination of therapeutic measures, including statins, ezetimibe, lipoprotein apheresis and evolocumab, is a significant determinant of survival in homozygous FH.

References

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Extent of serum cholesterol-lowering associates with survival in homozygous FH

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