Physicians' Academy for Cardiovascular Education

Subcutaneous fat cell lipolysis independent contributor to variations in plasma lipids

Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels

Literature - Rydén M and Arner P - Arterioscler Thromb Vasc Biol. 2017 Jun 29, Epub ahead of print

Main results


In this study, resistance to the antilipolytic effect of insulin and a high rate of basal lipolysis are associated with low HDL-c and high triglyceride levels. This was independent of classical risk factors influencing plasma lipids. Moreover, antilipolytic insulin sensitivity and basal lipolytic activity together explained 14% of variations in plasma triglycerides or HDL-c, thereby suggesting clinical importance for dyslipidemia.


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