Physicians' Academy for Cardiovascular Education

Herpes zoster enhances risk of stroke and myocardial infarction

Herpes Zoster Increases the Risk of Stroke and Myocardial Infarction

Literature - Kim M, Yun S, Lee HB, et al. - JACC 2017;70:295-296


The association between herpes zoster and stroke and myocardial infarction (MI) is still unclear. This uncertainty is partly due to the presence of many confounding factors, for which has not been adequately corrected in previous studies.

To take this confounding into account, 519,880 Korean people were followed from 2002 to 2013 to assess the association between newly diagnosed herpes zoster and the composite of stroke and MI, by propensity scoring matching and comprehensive adjustment for confounding.

Main results


Herpes zoster significantly increased the risk of stroke and MI in all age groups after adjusting for possible confounding factors in a large population cohort. Risks were especially high in the younger who have fewer risk factors for atherosclerosis. Moreover, there was a temporal link between herpes zoster and the development of stroke and MI.

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