Physicians' Academy for Cardiovascular Education

Mendelian randomization confirms association BMI and cardio-metabolic diseases

Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank

A Mendelian Randomization Study

Literature - Lyall DM, Celis-Morales C, Ward J, et al. - JAMA Cardiology 2017; published online ahead of print

Main results


In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate. These findings confirm that BMI represents an important modifiable risk factor for decreasing the risk of cardio-metabolic diseases in the general population.


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Find this article online at JAMA Cardiol

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