Physicians' Academy for Cardiovascular Education

Lipid transfer to HDL and HDL-c levels impaired in long-term bedridden patients

Lipid transfers to HDL are diminished in long-term bedridden patients: association with low HDL-cholesterol and increased inflammatory markers

Literature - de Oliveira WPC, Tavoni TM, Freitas FR et al., - Lipids. 2017. doi: 10.1007/s11745-017-4274-x.[Epub ahead of print]

Main results

No differences were seen in levels of apoB, CETP and LCAT, as well as glucose, insulin and leptin.


This study showed that the transfer of all four lipids to HDL was impaired in bedridden patients, as compared with sedentary subjects. This may be related to their lower HDL-c levels, as suggested by disappearance of the effect upon normalization by HDL-c levels or Apo A-I. Thus, the diminished lipid transfer does not seem to be the consequence of impaired ability of HDL particles to receive cholesterol. The data suggest that even low levels of physical activity exerted in the day-to-day life of sedentary subjects support HDL concentration and lipid transfer rates, as compared with complete inactivity.

The unexpected finding that LDL-c was lower in bedridden patients, may be explained by the standard infirmary diet that the patients received, with presumably lower calorie and fat intake compared with the free-living control sedentary subjects.


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