Physicians' Academy for Cardiovascular Education

Long working hours associated with an increased risk for atrial fibrillation

Long working hours as a risk factor for atrial fibrillation: a multi-cohort study

Literature - Kivimäki M, Nyberg ST, Batty GD, et al. - European Heart Journal 2017; published online ahead of print

Main results


In a large-scale meta-analysis, participants working over 55 hours per week were 40% more likely to develop AF compared with those working standard hours. This association was independent of known AF risk factors.

Editorial comment

In their editorial article, Mahmoodi and Boersma summarize the results of the Kivimaki et al study, and note: ‘It is worth noting that the individual studies were all underpowered to detect statistically significant associations; the authors should be congratulated for the impressive collaborative effort required to integrate patient-level data from multiple studies to increase the power.’

They also point out the study limitations, the most important being:

  • Possible changes regarding the working hours and the adjustment variables during the long follow-up period are lacking.
  • Other potential confounders, like the kind of work, expanding from office jobs to jobs that are physically demanding, or irregular working hours, including night shifts, are not taken into account.

The authors conclude: ‘Although the results of the present study apparently identify an association between working hours and AF, whether the relationship is causal or not remains to be determined. The results provide no insight into the mechanism by which working hours may affect the heart leading to development of AF. Intuitively, one would suspect the usual pathways causing changes in autonomic tone and increasing atrial fibrosis resulting in AF, but no evidence yet exists to prove such a mechanism.’


Show references

Find this article online at Eur Heart J

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