Physicians' Academy for Cardiovascular Education

PCSK9 loss-of-function variants associate with lower LDL-C

PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke. Data From 9 Studies of Blacks and Whites

Literature - Kent ST, Rosenson RS, Avery CL, et al. - Circ Cardiovasc Genet. 2017 Aug;10(4):e001632

Main results


In a meta-analysis of 17 459 black individuals and 31 306 white participants from nine studies, PCSK9 LOF variants were associated with lower LDL-C levels and CHD risk, which was more prominent among black compared to white individuals. On the other hand, PCSK9 LOF variants were not associated with stroke risk. These results suggest that lifetime lower LDL-C levels are associated with lower CHD risk and support a dose-response association between LDL-C and CHD.


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