Physicians' Academy for Cardiovascular Education

ApoA-I not superior to HDL-c to predict coronary heart disease

Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women’s Health Study

Literature - Van Capelleveen JC, Bochem AE, Boekholdt M, et al. - JAHA 2017, Epub ahead of print

Main results


In the EPIC-Norfolk cohort, HDL-c and apoA-I were strongly and inversely associated with CHD risk. However, these associations were not interchangeable as apoA-I levels did not show a similar trend within HDL-c quartiles, while vice versa, this was. Therefore, apoA-I levels do not offer predictive information over and above HDL-c. In contrast, an unexpected trend was even observed towards increased risk in some apoA-I quartiles. This was supported by a positive association of apoA-I levels with CHD risk factors within all HDL-c quartiles. All observations were confirmed in two independent cohorts, suggesting biological relevant associations.


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