Physicians' Academy for Cardiovascular Education

Novel insights into causal pathways in type 2 diabetes

A Mendelian Randomization Study of Metabolite Profile, Fasting Glucose and Type 2 Diabetes

Literature - Liu J, Bert van Klinken J, Semiz S, et al. - Diabetes 2017; published online ahead of print

Main results


Mendelian randomization provided evidence for potentially causal metabolic pathways of glucose homeostasis and T2DM. These findings indicate that an increase of large HDL particles might have a decreasing effect on glucose, while the opposite is the case with triglycerides and small HDL particles, suggesting them as targets for glucose management.


Show references

Find this article online at Diabetes

Share this page with your colleagues and friends: