Physicians' Academy for Cardiovascular Education

Cholesterol absorption inhibitor plus statin as secondary prevention protects against ischemic stroke

Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients with Acute Coronary Syndrome in IMPROVE-IT

Literature - Bohula EA, Wiviott SD, Giugliano RP, et al. - Circulation 2017; published online ahead of print

Main results

Conclusion

In the IMPROVE-IT study, the addition of ezetimibe to simvastatin in stabilized post-ACS patients reduced the frequency of ischemic stroke, particularly in patients with a history of prior stroke. These data support the addition of ezetimibe to a moderate-high intensity statin regimen for the prevention of ischemic stroke in stabilized post-ACS patients, particularly if they had a history of stroke prior to their ACS event.

References

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