Physicians' Academy for Cardiovascular Education

Lipid parameters strongly depend on age and sex

Lipid and lipoprotein reference values from 133,450 Dutch Lifelines participants: Age- and gender-specific baseline lipid values and percentiles

Literature - Balder JW, de Vries JK, Nolte IM, et al., - J Clin Lipidol. 2017; 11 (4): 1055–1064.e6

Main results


These data of the three-generation Lifelines cohort show prominent gender- and age-related differences in all main plasma lipids and lipoproteins, suggesting the need to correct for age and sex when evaluating a person’s lipid profile.

The prevalence of high LDL-c in young individuals was higher in this region of the Netherlands than anticipated. The presented data and the accompanying website can facilitate evaluation of (population) interventions or be used as a comparator for other prospective or retrospective lipid profile analyses in other geographic regions. The interactive website may serve as a tool to identify young individuals with atherogenic dyslipidemia.


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