Potent P2Y12 receptor inhibitor shows stronger antithrombotic effect in T2DM patients with CVD
A randomized, cross-over study showed a stronger antiplatelet effect and a faster and more potent antithrombotic effect with ticagrelor than with clopidogrel in T2DM patients with stable CVD.
Literature - Zafar MU, Baber U, Smith DA, et al. - Thromb Haemost 2017, published online ahead of printMain results
- Treatment with clopidogrel resulted in a reduction of 16%, 20% and 17% of thrombus size at high shear at 2 hours, 6 hours and 7 days, with only a significant reduction for the 6 hour timepoint. In contrast, treatment with ticagrelor resulted in a significantly reduced thrombus size at each timepoint (33%, 40% and 31%, respectively). Also, a significant difference in thrombus size was found between treatment with ticagrelor and clopidogrel at the 6 hour timepoint.
- A similar pattern was observed for thrombus formation at low shear, although reductions in thrombus size were smaller, since platelets do not play a major role under these conditions.
- Multiple electrode aggregation showed reductions of 46%, 56% and 54% with clopidogrel treatment at 2 hours, 6 hours, and 7 days, respectively. After treatment with ticagrelor, reductions in aggregation from baseline were larger (79%, 79% and 15%, respectively). At each timepoint, platelet aggregation with ticagrelor treatment was significantly lower than the aggregation with clopidogrel.
- Platelet aggregation as measured with VerifyNow showed a similar pattern with a more profound difference between treatment with ticagrelor and clopidogrel, with lower P2Y12 reaction units (PRU) for ticagrelor (42 vs 220 at 2 hours, 23 vs 189 at 6 hours, and 41 vs 177 at 7 days).
Conclusion
This randomized, cross-over trial demonstrated that treatment with ticagrelor resulted in a stronger inhibition of platelet aggregation, and more importantly, a more potent antithrombotic effect than clopidogrel in T2DM patients with stable CVD.
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