Physicians' Academy for Cardiovascular Education

High risk of ischemic and hemorrhagic events in AF patients with OAC contraindication

Patients With Atrial Fibrillation Who Are Not on Anticoagulant Treatment Due to Increased Bleeding Risk Are Common and Have a High Risk of Stroke

Literature - Redfors B, Gray WA, Lee RJ, et al. - JACC Clinical Electrophysiology 2017; published online ahead of print

Main results


A considerable number of patients with AF are not treated with OAC because of a bleeding-related contraindication, although they are considered to have high stroke risk according to their CHADS₂ or CHA₂DS₂-VASc score. These data show that these OAC-naive patients have a considerably high risk of ischemic and hemorrhagic stroke events, as well as death, and these risks are particularly high in patients with previous intracranial hemorrhage. These results suggest that new ways to prevent stroke are needed in this population.


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