Physicians' Academy for Cardiovascular Education

Diabetes and microvascular complications predict outcomes in HFpEF

The Prognostic Significance of Diabetes and Microvascular Complications in Patients With Heart Failure With Preserved Ejection Fraction

Literature - Sandesara PB, O’Neal WT, Kelli HM, et al. - Diabetes Care 2017; published online ahead of print

Main results


In the TOPCAT study, diabetes and its microvascular complications carried important prognostic information regarding adverse outcomes in HFpEF patients. In addition, the microvascular disease burden predicts HF re-hospitalization in this high-risk group. These findings show that additional preventive strategies to reduce morbidity and mortality in HFpEF patients with DM are needed.


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