Physicians' Academy for Cardiovascular Education

WOSCOPS analysis supports LDL-C lowering for primary prevention at high LDL-c without risk assessment

LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up

Literature - Vallejo-Vaz AJ, Robertson M, Catapano AL, et al. - Circulation 2017; 136:1878-91

Main results

Conclusion

Men with LDL-C levels ≥190 mg/dL without atherosclerotic CVD, have a 2-fold higher risk of major CV events than would be predicted with a risk calculator. These results provide evidence for the benefits of LDL-C lowering for the primary prevention of individuals with primary elevations of LDL-C ≥190 mg/dL, which may help reinforce current recommendations for this group of patients.

References

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