Physicians' Academy for Cardiovascular Education

PCSK9 LOF variants and low LDL-c levels not associated with neurocognitive impairment

PCSK9 Variants, LDL-Cholesterol, and Neurocognitive Impairment: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Literature - Mefford MT, Rosenson RS, Cushman M, et al. - Circulation 2017; published online ahead of print

Main results

Conclusion

In a large prospective cohort of African-Americans, PCSK9 LOF variants and lower LDL-C levels were not associated with neurocognitive impairment. These results suggest that life-long exposure to low PCSK9 levels and the resulting low levels of LDL-C do not have major effects on neurocognitive outcomes.

References

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