Physicians' Academy for Cardiovascular Education

HFrEF patients with low SBP do tolerate target dose of ARNI

Impact of systolic blood pressure on the safety and tolerability of initiating and up-titrating sacubitril/valsartan in patients with heart failure and reduced ejection fraction: insights from the TITRATION study

Literature - Senni M, McMurray JJV, Wachter R, et al. - Eur J Heart Fail 2017; published online ahead of print

Main results


In a post hoc analysis of the TITRATION study, the majority of patients with low SBP levels at screening tolerated the initiation/up-titration to target dose level of sacubitril/valsartan using a gradual up-titration regimen. These findings suggest that low screening SBP levels should not prevent clinicians from considering the initiation of sacubitril/valsartan.


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Find this article online at Eur J Heart Fail

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