Physicians' Academy for Cardiovascular Education

Midlife systemic inflammation may promote the development of white matter dysfunction

Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study

Literature - Walker KA, Power MC, Hoogeveen RC, et al. - Stroke 2017;48: 3196-3202

Main results


In a sub-analysis of the ARIC study, midlife systemic inflammation was associated with the development of chronic microangiopathic structural WM abnormalities in the elderly. These results provide insight into the temporal relationship between systemic inflammation and brain health and support the hypothesis that systemic inflammation plays a role in the pathogenesis of late-life WM dysfunction.


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