Physicians' Academy for Cardiovascular Education

Differential associations seen between Lp(a) levels and stroke, depending on AF-status

Associations of Lipoprotein(a) Levels With Incident Atrial Fibrillation and Ischemic Stroke: The ARIC (Atherosclerosis Risk in Communities) Study

Literature - Aronis KN, Zhao D, Hoogeveer RC et al., - J Am Heart Assoc. 2017;6:e007372. Originally published December 15, 2017

Main results


In this large community-based cohort, no association was observed between elevated Lp(a) levels and AF risk, in black nor whites, and in men nor women. Participants in the highest Lp(a) category (≥50 mg/dL) without AF did show a 40% higher risk of ischemic stroke, as compared with the lowest Lp(a) category (<10 mg/dL). This elevated risk is, however about 10-fold lower than the risk of stroke conveyed by AF itself.


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