Physicians' Academy for Cardiovascular Education

PCSK9 inhibitor changes levels and sizes of lipoprotein particles

Effect of Evolocumab on Lipoprotein Particles

Literature - Toth PP, Sattar N, Blom DJ, et al. - Am J Cardiol 2018;121:308–314

Main results


Evolocumab significantly changes lipoprotein particle number and size. Treatment with the PCSK9 inhibitor was associated with lower concentrations of total LDL-c, small LDL-p and large LDL-p. These findings may help guide therapeutic decisions in patients with hyperlipidemia.


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