Physicians' Academy for Cardiovascular Education

Remnant cholesterol determines CV risk in APOC3 LOF heterozygotes

APOC3 Loss-of-Function Mutations, Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Cardiovascular Risk: Mediation and Meta-Analyses of 137 895 Individuals

Literature - Wulff AB, Nordestgaard BG and Tybjærg-Hansen A. - Arterioscler Thromb Vasc Biol 2018;38: published online ahead of

Main results


The lower IVD risk in APOC3 LOF heterozygotes compared with non-carriers is largely due to the significantly lower levels of remnant cholesterol and not due to lower levels of LDL-c, and this observation was not affected by lipid-lowering therapy. These findings might be importantmay point at APOC3 and remnant cholesterol as therapeutic targets for CV prevention.


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